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non-vascular mortality

Statins have no impact on non-vascular mortality


There were concerns, derived in part from observational data and partly from pre-statin lipid-lowering intervention trials, that lowering cholesterol might increase the risk of non-vascular mortality. The CTT Collaboration conducted meta-analyses of combined data from large randomized controlled trials of statin therapy to address this uncertainty.


Individual participant data meta-analyses from randomized trials of statin therapy were performed. Initial analyses included 14 trials of statin versus control (involving approximately 90,000 individuals) with subsequent analyses including a total of >20 trials of statin versus control (involving approximately 135,000 individuals). Median follow-up was approximately 5 years.


No significant effects observed on non-vascular causes of death:

  • Overall
  • From cancer, respiratory disease, trauma, or all other non-vascular disease
  • In individuals with lower baseline LDL cholesterol concentrations
  • By gender