Statins have no impact on non-vascular mortality
There were concerns, derived in part from observational data and partly from pre-statin lipid-lowering intervention trials, that lowering cholesterol might increase the risk of non-vascular mortality. The CTT Collaboration conducted meta-analyses of combined data from large randomized controlled trials of statin therapy to address this uncertainty.
Individual participant data meta-analyses from randomized trials of statin therapy were performed. Initial analyses included 14 trials of statin versus control (involving approximately 90,000 individuals) with subsequent analyses including a total of >20 trials of statin versus control (involving approximately 135,000 individuals). Median follow-up was approximately 5 years.
No significant effects observed on non-vascular causes of death:
- From cancer, respiratory disease, trauma, or all other non-vascular disease
- In individuals with lower baseline LDL cholesterol concentrations
- By gender